Statin use associated with a 52% increased risk of Interstitial cystitis

This study was published in Urologia Internationalis 2015 Jul 16

 

Study title and authors:

Statin Use Is Associated with Bladder Pain Syndrome/Interstitial Cystitis: A Population-Based Case-Control Study.

Huang CY, Chung SD, Kao LT, Lin HC, Wang LH.

Department of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei, Taiwan.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/26184102

This study examined the association between statin use and bladder pain syndrome/interstitial cystitis. The study included 815 female subjects with bladder pain syndrome/interstitial cystitis and 4,075 randomly selected female controls.

The study found that statin users had a 52% increased risk of bladder pain syndrome/interstitial cystitis compared to nonusers.

Low levels of LDL cholesterol associated with a 65% increased risk of death in heart attack patients

This study was published in Critical Care Medicine 2015 Jun;43(6):1255-64

Study title and authors:
Lipid paradox in acute myocardial infarction-the association with 30-day in-hospital mortality.

Cheng KH, Chu CS, Lin TH, Lee KT, Sheu SH, Lai WT.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25738856

The Killip classification (four classes - I to IV) is a system used in individuals with a heart attack. Individuals with a low Killip class are less likely to die within the first 30 days after their heart attack than individuals with a high Killip class.

This study was designed to clarify the relationship between cholesterol levels, Killip classification, and 30-day mortality in patients with a heart attack. The study included 724 heart attack patients.

The study found:
(a) Low-density lipoprotein (LDL) cholesterol and triglyceride levels were significantly lower in high-Killip (III + IV) patients compared with low-Killip (I + II) patients.
(b) Patients with low-density lipoprotein (LDL) cholesterol less than 62.5 mg/dL (1.6 mmol/L) had a 65% increased risk of death compared with patients with patients with low-density lipoprotein (LDL) cholesterol more than 62.5 mg/dL (1.6 mmol/L).
(c) Patients with triglyceride levels less than 110 mg/dL (1.24 mmol/L) had a 405% increased risk of death compared with patients with patients with triglyceride levels more than 110 mg/dL (1.24 mmol/L).
(d) Patients with a high-Killip classification and with with triglycerides less than 62.5 mg/dL (1.6 mmol/L) and low-density lipoprotein (LDL) cholesterol less than 110 mg/dL (1.24 mmol/L) had a 10.9-fold higher risk of death than patients with a low-Killip classification with triglycerides greater than 62.5 mg/dL (1.6 mmol/L) and low-density lipoprotein (LDL) cholesterol greater than 110 mg/dL (1.24 mmol/L).

Cheng concluded: "Low low-density lipoprotein (LDL) cholesterol, low triglycerides, and high Killip severity were associated with significantly higher 30-day in-hospital mortality in patients presenting with acute myocardial infarction".

High red meat consumption associated with a 9% reduction in death from diabetes

This study was published in BMC Public Health 2015 Jul 10;15(1):633

 

Study title and authors:

Spatiotemporal variation in diabetes mortality in China: multilevel evidence from 2006 and 2012.

Zhou M, Astell-Burt T, Yin P, Feng X, Page A, Liu Y, Liu J, Li Y, Liu S, Wang L, Wang L, Wang L.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing, 100050, China. maigengzhou@126.com.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/26159911

This study investigated diabetes death rates. The six year study included data from 73 million people.

Regarding red meat consumption, the study found, those who consumed the most red meat had a 9% lower death rate from diabetes than those who consumed the least red meat.

Regarding cholesterol levels, the study found, those who had the highest cholesterol levels had a 3% lower death rate from diabetes compared to those who had the lowest cholesterol levels.

Statin use is associated with weight gain and a large increase in diabetes

This study was published in the Journal of the American Medical Association International Medicine 2014 Apr 24

 

Study title and authors:

Different Time Trends of Caloric and Fat Intake Between Statin Users and Nonusers Among US Adults: Gluttony in the Time of Statins?

Sugiyama T, Tsugawa Y, Tseng CH, Kobayashi Y, Shapiro MF.

Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles2Department of Public Health/Health Policy, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan3Depa.

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/24763487

This study examined the effects of statins on caloric intake, weight gain and diabetes. The study lasted eleven years and included 27,886 adults, 20 years or older, who completed a 24-hour dietary recall.

The study found over an 11 year period:
(a) The caloric intake of statin users increased by 9.6%.
(b) The caloric intake of non users DECREASED by 1.9%.
(c) The BMI of statin user increased by 1.3
(d) The BMI of non users increased by 0.5
(e) Diabetes increased by 7.8% in statin users.
(f) Diabetes DECREASED by 0.4% in non users.

This study shows statin use is associated with weight gain and a large increase in diabetes.