Statins deplete vitamin E and coenzyme Q10 levels in type two diabetic patients

This study was published in Clinica Chimica Acta 2001 Sep 25;311(2):91-4

 

Study title and authors:

Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients.

Oranje WA, Sels JP, Rondas-Colbers GJ, Lemmens PJ, Wolffenbuttel BH.

Department of Endocrinology and Metabolism, University Hospital Maastricht, Maastricht, The Netherlands. Oranje@rdgg.nl

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/11566168

This study investigated the effects of statins in type two diabetic patients. The three month study included 19 patients who received either atorvastatin or placebo.

The study found:
(a) The alpha-tocopherol (vitamin E) levels of patients receiving atorvastatin reduced by 38%.
(b) The ubiquinol (ubiquinol is the active form of coenzyme Q10) levels of patients receiving atorvastatin reduced by 37%.

Diabetic women who die of heart disease consume less saturated fat

This study was published in Diabetes Care 2003 Mar;26(3):619-24

Study title and authors:
Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes.

Soinio M, Laakso M, Lehto S, Hakala P, Rönnemaa T.
Department of Medicine, University of Turku, Turku, Finland. minna.soinio@tyks.fi

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12610011

The aim of the study was to investigate whether dietary fat predicts coronary heart disease events in middle-aged type two diabetic subjects. In the study the dietary habits of 366 type two diabetic men and 295 women, aged 45-64 years and free from coronary heart disease, were assessed with a 53-item food frequency questionnaire. They were followed up for seven years.

The study found:
(a) Women who died of heart disease consumed 7.7% less fat compared to the other women in the study.
(b) Women who died of heart disease consumed 7.5% less saturated fat compared to the other women in the study.
(c) Men who died of heart disease consumed 1.7% less fat compared to the other men in the study.
(d) Men who died of heart disease consumed 0.5% less saturated fat compared to the other men in the study.

Statins increase risk of diabetes by 32% in patients with impaired glucose tolerance

This study was published in the British Medical Journal 9 December 2013;347:f6745 

Study title and authors:
Role of diuretics, β blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study

Lan Shen

 

This study can be accessed at: http://www.bmj.com/content/347/bmj.f6745?rss=1

 

The objective of this study was to examine the association of various drugs in patients with impaired glucose tolerance with new onset diabetes. The study lasted five years and included 9,306 patients. (If you have impaired glucose tolerance, your blood glucose is raised beyond the normal range but it is not so high that you have diabetes. However, if you have impaired glucose tolerance you are at risk of developing diabetes).

 

Regarding statins, the study found that statin use was associated with a 32% increased risk of new onset diabetes.